Įndorphins receptors are increased during stress such as inflammation binds abruptly with endorphins. Įndorphins are produced during pranayama, mindful meditation, pranic healing, intense physical exercise creates a psychological relaxed state known as “Runnerʼs high”, Love, sex, Tender, care, music therapy, acupuncture, Care, Sympathy and Empathy in caring the patient involved in immune stimulatory activity, stress buster activity (Tranquility of mind), anti-inflammatory activity, and analgesic activity. Betaendorphin is an abundant endorphin, more potent than morphine, synthesized and stored in the anterior pituitary gland, it is a precursor of POMC (Proopiomelanocortin). There are three types of endorphins betaendorphin, enkephalin, and dynorphin binds to mu, kappa, and delta receptors situated on nervous system and immune cells. Endorphins are endogenous morphine, neuropeptides produced in the pituitary gland, response to stress and pain. Advanced cancer treatment modalities such as surgery, radiotherapy, chemotherapy failed to improve the prognosis of cancer with increasing morbidity, adverse drug reactions, and decreased survival rate. Chronic inflammation is considered as a seventh hall mark of cancer.
#ENDORPHIN RECEPTORS FREE#
These external environmental factors induced chronic inflammatory mediators such as cytokines, growth factors, proteolytic enzymes such as IL-1β,TNF-α, and COX-2 activate NF-KB a key transcription factors and IL-6, EGF, FGF, PDGF inflammatory mediators activate STAT-3 transcription factor, both transcription factors work together express inflammatory mediators involved in tumor progression by cell proliferation (Cyclin D, Cyclin E), cell survival (BCL-2, BCL-XL), angiogenesis (IL-8, VEGF, COX-2), genomic instability (ROS, RNS free radicals), invasion and metastasis (up A, MMPʼs 2,9).Ĭhronic psychological stress is one of the etiological factor for cancer. Majority of cancers more than 90% of all cancers are due to external environmental factors such as tobacco, alcohol, infectious agents such as (HPV, EBV), inhalation of chemical agents such as silica, arsenic, benzene, lead leads to various types of cancers. Most important causative factor for human diseases including cancer is human environment most important part of human environment is human mind. Human body works as a whole, if we consider human body as a whole rather than as parts in treating any disease with reductionist chemical drugs yeild better results without adverse effects.
Holistic healing is a whole person healing. Keywords: NF-KB STAT-3 Cortisol ACTH Noradrenaline INF-γ Opsonin Granzyme-B. This article highlights about the basic research findings of anti-tumor activity of beta-endorphin. Beta-endorphin, has got various mechanisms of actions such as analgesic activity, stress buster activity, anti-inflammatory activity, and immune stimulatory activity, because of these mechanisms of actions it can be useful in holistic preventive, therapeutic, health promotive and palliative management of cancer without adverse effects. Beta-endorphin is an abundant endorphin, more potent than morphine, synthesized and stored in the anterior pituitary gland. Endorphins are endogenous morphine, neuropeptides produced in the pituitary gland.
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